Virchows Archiv. Invasive breast cancer comprises a spectrum of histological changes with purely lobular cancer on one side and purely ductal cancer on the other, with many mixed lesions in between. In a previous study, we showed that in patients with any percentage lobular component at core needle biopsy, preoperative MRI leads to the detection of clinically relevant additional findings in a substantial percentage of patients, irrespective of the percentage of the lobular component.
When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken. Information in this report will be used to help manage your care.
Objectives: Breast cancer is one of the most common malignancies in women, and the tumor cells' invasion and metastasis is the main cause of death. Recent reports showed that Twist, a transcription factor, plays multiple roles in breast cancer initiation, progress, and metastasis. However, the underlying mechanisms of Twist in tumor invasion and metastasis of breast cancer still remain unclear.
Aberrant expression of E-cadherin has been associated with the development of metastases in patients with breast cancer. Even though the expression of E-cadherin has been studied in primary breast tumors, little is known about its expression at the distant metastatic sites. We investigate the relationship between E-cadherin expression in primary breast carcinoma and their distant, non-nodal metastases. Immunohistochemical analysis of E-cadherin was performed in tissues from 30 patients with primary invasive breast carcinoma and their distant metastases.
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Among women in the world, breast cancer is the most common cancer with an estimated 1. Although comprehensive treatment is available, including radical surgery and adjuvant therapy, the prognosis of breast cancer patients is still far from optimistic [ 2 ]. Several common clinicopathological parameters, which include tumor size, lymph node status, histological grade, estrogen receptor ERprogesterone receptor PR and human epidermal growth factor-2 HER-2 have been extensively applied in the clinic [ 3 ].
A patient with prior invasive lobular breast cancer had a new lump detected in the right breast with overlapping features of ductal and lobular carcinoma, requiring an E-cadherin stain. E-cadherin results showed a ductal carcinoma. A 56 year old asymptomatic female had a positive family history for breast cancer.
Impact factor 3. International Journal of Biological Sciences. International Journal of Medical Sciences.
The biological characteristics of the tumour are used to estimate prognosis and select appropriate systemic therapy for patients with breast cancer. The advent of molecular technology has incorporated new biomarkers along with immunohistochemical and serum biomarkers. Immunohistochemical markers are often used to guide treatment decisions, to classify breast cancer into subtypes that are biologically distinct and behave differently, and both as prognostic and predictive factors. Steroid hormone receptors, markers of tumour proliferation, and factors involved in angiogenesis and apoptosis are of scientific interest.